As a part of our ongoing efforts to develop tools with our colleagues in biology, we have designed and synthesized trifunctional linkers for expansion microscopy that overcome signal loss. This is a fruitful collaboration with Bo Huang and colleagues, and has enabled the highest resolution (5-nm) ExM to date!!
Also, this is our second preprint upload. I sense a trend starting…
Congrats to the team, especially the leaders Xiaoyu and Qi!
With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (bit.ly/2xlFS2q), making this our first pre-print (by only a few hours! see next post…)
We are very proud of this story. It features >60 structurally complex analogs, >8 cryo-EM structures, and hundreds of MICs. And a 250+-page Supporting Information. Congrats to Qi, Jenna, and the whole team!!
Ian was awarded the Packard Fellowship in Science and Engineering! The lab is very proud, and looking forward to our next Hot Pot outing…
Ian was selected as a 2018 Beckman Young Investigator!! Thank you to the Beckman Foundation for believing in our mission to create new antibiotics using chemical synthesis. We are thrilled to be included in this prestigious program!!!
Qi has completed an elegant synthesis of group A streptogramin antibiotics (on gram scale)! We had to teach him how to pop champagne when we submittted. Now he’ll be a veteran when we have the acceptance party.
Find his paper over at the Journal of the American Chemical Society.
Thrilled to share some of my opinions on antibiotics and superbugs with Chemistry World!