As a part of our ongoing efforts to develop tools with our colleagues in biology, we have designed and synthesized trifunctional linkers for expansion microscopy that overcome signal loss. This is a fruitful collaboration with Bo Huang and colleagues, and has enabled the highest resolution (5-nm) ExM to date!!
Also, this is our second preprint upload. I sense a trend starting…
Congrats to the team, especially the leaders Xiaoyu and Qi!
With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (bit.ly/2xlFS2q), making this our first pre-print (by only a few hours! see next post…)
We are very proud of this story. It features >60 structurally complex analogs, >8 cryo-EM structures, and hundreds of MICs. And a 250+-page Supporting Information. Congrats to Qi, Jenna, and the whole team!!
Seul Ki Yeon, who got her PhD in medicinal chemistry at the Korean Institute of Science and Technology, has joined the lab! She will be working on several creative ways to inhibit ribosome function. Welcome!!
Yanmin and Lingchao have synthesized and structurally reassigned the only acyclic member of the lankacidin group of antibiotics! Congrats on the well-deserved publication in Angewandte Chemie International Edition.
Ian was selected as a 2018 Beckman Young Investigator!! Thank you to the Beckman Foundation for believing in our mission to create new antibiotics using chemical synthesis. We are thrilled to be included in this prestigious program!!!
In the past month or so, we have celebrated the birthdays of both of our talented rotating students (Neha and Megan, although Megan doesn’t know it yet…) as well as our very tired PI. We definitely enjoy any excuse to have champagne/sweets in the middle of a work day…
Qi has completed an elegant synthesis of group A streptogramin antibiotics (on gram scale)! We had to teach him how to pop champagne when we submittted. Now he’ll be a veteran when we have the acceptance party.