Author: ianseiple

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  • Our second pre-print: Label Retention Expansion Microscopy!

    As a part of our ongoing efforts to develop tools with our colleagues in biology, we have designed and synthesized trifunctional linkers for expansion microscopy that overcome signal loss. This is a fruitful collaboration with Bo Huang and colleagues, and has enabled the highest resolution (5-nm) ExM to date!! Also, this is our second […] Read more

  • The big streptogramin story, complete with 250-pg SI.

    With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (, making this our first pre-print (by only a few hours! see next post…) We are very proud of this story. It features >60 structurally complex analogs, […] Read more

  • Welcome Seul Ki!!

    Seul Ki Yeon, who got her PhD in medicinal chemistry at the Korean Institute of Science and Technology, has joined the lab! She will be working on several creative ways to inhibit ribosome function. Welcome!! Read more

  • Packard

    Ian was awarded the Packard Fellowship in Science and Engineering! The lab is very proud, and looking forward to our next Hot Pot outing… Read more

  • Congrats Yanmin and Lingchao!

    Yanmin and Lingchao have synthesized and structurally reassigned the only acyclic member of the lankacidin group of antibiotics! Congrats on the well-deserved publication in Angewandte Chemie International Edition. Read more

  • Beckman Young Investigator Announcement

    Ian was selected as a 2018 Beckman Young Investigator!! Thank you to the Beckman Foundation for believing in our mission to create new antibiotics using chemical synthesis. We are thrilled to be included in this prestigious program!!! Read more

  • So many birthdays!

    In the past month or so, we have celebrated the birthdays of both of our talented rotating students (Neha and Megan, although Megan doesn’t know it yet…) as well as our very tired PI. We definitely enjoy any excuse to have champagne/sweets in the middle of a work day… Read more

  • Congratulations, Qi!

    Qi has completed an elegant synthesis of group A streptogramin antibiotics (on gram scale)! We had to teach him how to pop champagne when we submittted. Now he’ll be a veteran when we have the acceptance party. Find his paper over at the Journal of the American Chemical Society. Read more

  • Chemistry World Feature


    Thrilled to share some of my opinions on antibiotics and superbugs with Chemistry World! Read more