The big streptogramin story, complete with 250-pg SI.

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With an incredible, multidisciplinary team from UCSF and Schrodinger, we have been able to overcome streptogramin resistance caused by virginiamycin acetyltransferase! We have posted the results on ChemRXiv (bit.ly/2xlFS2q), making this our first pre-print (by only a few hours! see next post…)

We are very proud of this story. It features >60 structurally complex analogs, >8 cryo-EM structures, and hundreds of MICs. And a 250+-page Supporting Information. Congrats to Qi, Jenna, and the whole team!!