Publications

33. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice Nature Biotechnol. 2022 in press: doi: 10.1038/s41587-022-01386-z.

32. Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA. Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins ACS Chem. Biol. 2022, 17, 1259-1268. 

31. Prasad NK, Seiple IB, Cirz RT, Rosenberg OS. Leaks in the pipeline: a failure analysis of Gram-negative antibiotic development from 2010-2020 Antimicrob. Agents Chemother. 202265. ePub: https://doi.org/10.1128/aac.00054-22.

30. Cotton AD, Wells JA, Seiple IB. Biotin as a reactive handle to selectively label proteins and DNA with small molecules ACS Chem. Bio. 2021, in press. See also the ChemRxiv preprint.

29. Cotton AD,  Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. Development of antibody-based PROTACs for the degradation of the cell-surface immune checkpoint protein PD-L1 J. Am. Chem. Soc. 2020in press.

28. Li Q, Seiple IB. Modular synthesis of streptogramin antibiotics Synlett (Synpacts article), 2020, 31, A-H.

27. Li Q, Pellegrino J, Lee DJ, Tran AT, Chaires HA, Wang, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Mülle E, Chesneau O, Jacobson MP, Fraser JS, Seiple IB.  Synthetic group A streptogramin antibiotics that overcome Vat resistance Nature 2020, 586, 145-150.

Featured in Nature News & Views, UCSF News, and C&E News. Also see the ChemRxiv preprint.

26. Sundaram A, Chen C, Reed NI, Liu S, Leod SK, McIntosh J, Tang Y-Z, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsivenessBioorg. Med. Chem. Lett. 202030, 127578.

25. Boyce J, Dang B, Ary B, Edmondson Q, Craik C, DeGrado WF, Seiple IB. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates J. Am. Chem. Soc. 2020, 142, 21310-21321.

24. Cotton AD, Seiple IB. Examining Gender Imbalance in Chemistry Authorship. ACS Chem. Bio. 2021, in press. See also the BioRXiv preprint.

23. Cai L, Yao Y, Yeon SK, Seiple IB Modular Approaches to Lankacidin Antibiotics. J. Am. Chem. Soc. 2020142, 15116-15126.

22. Liu J., Cai L., Sun W., Cheng R., Wang N., Jin L., Rozovsky S., Seiple I. B., Wang L.* Photocaged Quinone Methide Cross-linkers for Light-controlled Chemical Cross-linking of Protein-protein and Protein-DNA Complexes. Angew. Chem. Int. Ed Engl. 2019, 58, 18839–18843.

21. Shi, X.*; Li, Q.*; Dai, Z.; Tran, A.; Feng, S.; Ramirez, A. S.; Lin, Z.; Wang, X.; Chow, T. T.; Seiple, I. B.; Huang, B. Label-retention expansion microscopy (preprint on BioRXiv).

20. Li, Q.; Seiple, I. B. A concise route to virigniamycin M2 Tetrahedron 201975, 3309–3318. Ryan Shenvi Young Investigator Award Special Issue

19. Yao, Y.*; Cai, L.*; Seiple, I. B. Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B Angew. Chem. Int. Ed. 201857, 13551–13554. See the feature in SynForm for the behind-the-scenes story!

18. Li, Q.; Seiple, I. B.; Modular, Scalable Synthesis of Group A Streptogramin Antibiotics J. Am. Chem. Soc. 2017, 139, 13304–13307.

17. Seiple, I. B.*; Zhang, Z.*; Jakubec, P.; Langlois-Mercier, A.; Wright, P. M.; Hog, D. T.; Yabu, K.; Allu, S. R.; Fukuzaki, T.; Carlsen, P. N.; Kitamura, Y.; Zhou, X.; Condakes, M. L.; Szczypinski, F. T.; Green, W. D.; Myers, A. G. A Platform for the Discovery of New Macrolide Antibiotics Nature 2016533, 338.  See also: News and Views.

16. Seiple, I. B.; Hog, D. T.; Myers, A. G. Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics Synlett 2015, 27, 57–60.

15. Wright, P. M.; Seiple, I. B.; Myers, A. G. The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery Angew. Chem. Int. Ed. 2014, 53, 8840–8869.15. Seiple, I. B.; Mercer, J. A. M.; Sussman, R. J.; Myers, A. G. Stereocontrolled Synthesis of Synβ-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide Angew. Chem. Int. Ed. 2014, 53, 4642–4647.

14. Seiple, I. B. Silver(II) Picolinate Encyclopedia of Reagents in Organic Synthesis 2012, DOI: 10.1002/047084289X.rn01408.

13. Lansdell, T. A.; Hewlett, N. M.; Skoumbourdis, A. P.; Fodor, M. D.; Seiple, I. B.; Su, S.; Baran, P. S.; Feldman, K. S.; Tepe, J. J. Palau’amine and Related Oroidin-Alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome J. Nat. Prod. 2012, 75, 980–985.

12. Köck, M.; Schmidt, G.; Seiple, I. B.; Baran, P. S. Configurational Analysis of Tetracyclic Dimeric Pyrrole–Imidazole Alkaloids using a Floating Chirality Approach J. Nat. Prod. 2012, 75, 127–130.

11. Seiple, I. B.; Su, S.*; Young. I. S*.; Nakamura, A.; Yamaguchi, J.; Jørgensen, L.; Rodriguez, R. A.; O’Malley, D. P.; Gaich, T.; Köck, M.; Baran, P. S. Enantioselective Total Syntheses of (–)-Palau’amine, (–)-Axinellamines, and (–)-Massadines J. Am. Chem. Soc. 2011, 133, 14710–14726.

10. Ji, Y.*; Brueckl, T.*; Baxter, R. D.; Fujiwara, Y.; Seiple, I. B.; Su, S.; Blackmond, D. G.; Baran, P. S. Innate C–H Trifluoromethylation of Heterocycles Proc. Nat. Acad. Sci. 2011, 108, 14411–14415. Cited over 200 times.

9. Fujiwara, Y.; Domingo, V.; Seiple, I. B.; Gianatassio, R.; Del Bel, M.; Baran, P. S. Practical C–H Functionalization of Quinones with Boronic Acids. J. Am. Chem. Soc. 2011, 133, 3292–3295.

8. Seiple, I. B.; Su, S.; Rodriguez, R.; Gianatassio, R.; Fujiwara, Y.; Sobel, A.; Baran, P. S. Direct C–H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids J. Am. Chem. Soc. 2010, 132, 13194–13196. Cited over 150 times.

7. Seiple, I. B.*; Su, S.*; Young, I. S.; Lewis, C. A.; Yamaguchi, J.; Baran, P. S. Total Synthesis of (±)-Palau’amine Angew. Chem. Int. Ed. 2010, 49, 1095–1098. Featured on the cover of the issue.

6. Su, S.; Seiple, I. B.; Young, I. S.; Baran, P. S. Total Synthesis of (±)-Massadine and Massadine Chloride J. Am. Chem. Soc. 2008, 130, 16490–16491.

5. O’Malley, D. P.; Yamaguchi, J.; Young, I. S.; Seiple, I. B.; Baran, P. S. Total Synthesis of (±)-Axinellamines A and B Angew. Chem. Int. Ed. 2008, 47, 3581–3583. Featured on the inside cover of the issue.

4. Yamaguchi, J.*; Seiple, I. B.*; Young, I. S.; O’Malley, D. P.; Maue, M.; Baran, P. S. Synthesis of 1,9-Dideoxy-Pre-Axinellamine Angew. Chem. Int. Ed. 2008, 47, 3578–3580.

3. Köck, M.; Grube, A.; Seiple, I. B.; Baran, P. S. The Pursuit of Palau’amine Angew. Chem. Int. Ed. 2007, 46, 6586–6594.

2. Liang, G.; Xu, Y.; Seiple, I. B.; Trauner, D. Synthesis of Taiwaniaquinoids via Nazarov Triflation. J. Am. Chem. Soc. 2006, 128, 11022–11023.

1. Liang, G.; Seiple, I. B.; Trauner, D. Stereoselective Syntheses of the Bioactive Polypropionates Aureothin, N-Acetylaureothamine, and Aureonitrile Org. Lett. 2005, 7, 2837–2839.

Patents (provisional patents excluded)

4. Myers, A. G.; Seiple, I. B.; Zhang, Z. Macrolides with Modified Desosamine Sugars and Uses Thereof. PCT/US2016/024333.

3. Myers, A. G.; Seiple, I. B., Zhang, Z. 14-Membered Ketolides and Methods of their Preparation and Use PCT/US2015/054700.

2. Myers, A. G.; Seiple, I. B.; Sussman, R. J. R. Monobactams and Methods of their Synthesis and Use PCT/US2015/10247.

  1. Myers, A. G.; Seiple, I. B.; Zhang, Z. Macrolides and Methods of their Preparation and Use PCT/US2014/033025.

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