24. Liu J., Cai L., Sun W., Cheng R., Wang N., Jin L., Rozovsky S., Seiple I. B., Wang L.* Photocaged Quinone Methide Cross-linkers for Light-controlled Chemical Cross-linking of Protein-protein and Protein-DNA Complexes. Angew. Chem. Int. Ed Engl. 2019, doi: 10.1002/anie.201910135.

23. Li, Q.*; Pellegrino, J.; Lee, D. J.; Tran, A. T.; Wang, R.; Park, J. E.; Ji, K.; Chow, D.; Zhang, N.; Brilot, A. F.; Biel, J. T.; van Zundert, G.; Borrelli, K.; Shinabarger, D.; Wolfe, C.; Murray, B.; Jacobson, M. P.; Fraser, J. S.; Seiple, I. B. Synthesis and mechanism of action of group A streptogramins that overcome resistance (preprint on ChemRXiv).

22. Shi, X.*; Li, Q.*; Dai, Z.; Tran, A.; Feng, S.; Ramirez, A. S.; Lin, Z.; Wang, X.; Chow, T. T.; Seiple, I. B.; Huang, B. Label-retention expansion microscopy (preprint on BioRXiv).

21. Li, Q.; Seiple, I. B. A concise route to virigniamycin M2 Tetrahedron 201975, 3309–3318. Ryan Shenvi Young Investigator Award Special Issue

20. Yao, Y.*; Cai, L.*; Seiple, I. B. Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B Angew. Chem. Int. Ed. 201857, 13551–13554. See the feature in SynForm for the behind-the-scenes story!

19. Li, Q.; Seiple, I. B.; Modular, Scalable Synthesis of Group A Streptogramin Antibiotics J. Am. Chem. Soc. 2017, 139, 13304–13307.

18. Seiple, I. B.*; Zhang, Z.*; Jakubec, P.; Langlois-Mercier, A.; Wright, P. M.; Hog, D. T.; Yabu, K.; Allu, S. R.; Fukuzaki, T.; Carlsen, P. N.; Kitamura, Y.; Zhou, X.; Condakes, M. L.; Szczypinski, F. T.; Green, W. D.; Myers, A. G. A Platform for the Discovery of New Macrolide Antibiotics Nature 2016533, 338.  See also: News and Views.

17. Seiple, I. B.; Hog, D. T.; Myers, A. G. Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics Synlett 2015, 27, 57–60.

  1. Wright, P. M.; Seiple, I. B.; Myers, A. G. The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery Angew. Chem. Int. Ed. 2014, 53, 8840–8869.
  1. Seiple, I. B.; Mercer, J. A. M.; Sussman, R. J.; Myers, A. G. Stereocontrolled Synthesis of Synβ-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide Angew. Chem. Int. Ed. 2014, 53, 4642–4647.
  1. Seiple, I. B. Silver(II) Picolinate Encyclopedia of Reagents in Organic Synthesis 2012, DOI: 10.1002/047084289X.rn01408.
  1. Lansdell, T. A.; Hewlett, N. M.; Skoumbourdis, A. P.; Fodor, M. D.; Seiple, I. B.; Su, S.; Baran, P. S.; Feldman, K. S.; Tepe, J. J. Palau’amine and Related Oroidin-Alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome J. Nat. Prod. 2012, 75, 980–985.
  1. Köck, M.; Schmidt, G.; Seiple, I. B.; Baran, P. S. Configurational Analysis of Tetracyclic Dimeric Pyrrole–Imidazole Alkaloids using a Floating Chirality Approach J. Nat. Prod. 2012, 75, 127–130.
  1. Seiple, I. B.; Su, S.*; Young. I. S*.; Nakamura, A.; Yamaguchi, J.; Jørgensen, L.; Rodriguez, R. A.; O’Malley, D. P.; Gaich, T.; Köck, M.; Baran, P. S. Enantioselective Total Syntheses of (–)-Palau’amine, (–)-Axinellamines, and (–)-Massadines J. Am. Chem. Soc. 2011, 133, 14710–14726.
  1. Ji, Y.*; Brueckl, T.*; Baxter, R. D.; Fujiwara, Y.; Seiple, I. B.; Su, S.; Blackmond, D. G.; Baran, P. S. Innate C–H Trifluoromethylation of Heterocycles Proc. Nat. Acad. Sci. 2011, 108, 14411–14415. Cited over 200 times.
  1. Fujiwara, Y.; Domingo, V.; Seiple, I. B.; Gianatassio, R.; Del Bel, M.; Baran, P. S. Practical C–H Functionalization of Quinones with Boronic Acids. J. Am. Chem. Soc. 2011, 133, 3292–3295.
  1. Seiple, I. B.; Su, S.; Rodriguez, R.; Gianatassio, R.; Fujiwara, Y.; Sobel, A.; Baran, P. S. Direct C–H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids J. Am. Chem. Soc. 2010, 132, 13194–13196. Cited over 150 times.
  1. Seiple, I. B.*; Su, S.*; Young, I. S.; Lewis, C. A.; Yamaguchi, J.; Baran, P. S. Total Synthesis of (±)-Palau’amine Angew. Chem. Int. Ed. 2010, 49, 1095–1098. Featured on the cover of the issue.
  1. Su, S.; Seiple, I. B.; Young, I. S.; Baran, P. S. Total Synthesis of (±)-Massadine and Massadine Chloride J. Am. Chem. Soc. 2008, 130, 16490–16491.
  1. O’Malley, D. P.; Yamaguchi, J.; Young, I. S.; Seiple, I. B.; Baran, P. S. Total Synthesis of (±)-Axinellamines A and B Angew. Chem. Int. Ed. 2008, 47, 3581–3583. Featured on the inside cover of the issue.
  1. Yamaguchi, J.*; Seiple, I. B.*; Young, I. S.; O’Malley, D. P.; Maue, M.; Baran, P. S. Synthesis of 1,9-Dideoxy-Pre-Axinellamine Angew. Chem. Int. Ed. 2008, 47, 3578–3580.
  1. Köck, M.; Grube, A.; Seiple, I. B.; Baran, P. S. The Pursuit of Palau’amine Angew. Chem. Int. Ed. 2007, 46, 6586–6594.
  1. Liang, G.; Xu, Y.; Seiple, I. B.; Trauner, D. Synthesis of Taiwaniaquinoids via Nazarov Triflation. J. Am. Chem. Soc. 2006, 128, 11022–11023.
  1. Liang, G.; Seiple, I. B.; Trauner, D. Stereoselective Syntheses of the Bioactive Polypropionates Aureothin, N-Acetylaureothamine, and Aureonitrile Org. Lett. 2005, 7, 2837–2839.

Patents (provisional patents excluded)

  1. Myers, A. G.; Seiple, I. B.; Zhang, Z. Macrolides with Modified Desosamine Sugars and Uses Thereof. PCT/US2016/024333.
  2. Myers, A. G.; Seiple, I. B., Zhang, Z. 14-Membered Ketolides and Methods of their Preparation and Use PCT/US2015/054700.
  3. Myers, A. G.; Seiple, I. B.; Sussman, R. J. R. Monobactams and Methods of their Synthesis and Use PCT/US2015/10247.
  4. Myers, A. G.; Seiple, I. B.; Zhang, Z. Macrolides and Methods of their Preparation and Use PCT/US2014/033025.